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Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats

Faisal, Ghasak Ghazi and Mustafa Al-Ahmad, Basma Ezzat and Najmuldeen, Ghazi Faisal and Mustafa, Nazih Shaban and Al-Ani, Ali Sabri Radeef and Althunibat, Osama Yousef (2015) Changes in leptin and testosterone hormones associated with Eurycoma Longifolia jack (Tongkat ali) root extract consumption in male rats. In: International Conference on Natural Products 2015, 24-25 March 2015, Double Tree by Hilton, Johor Bahru. (Unpublished)

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Objectives: To study the effects of Eurycoma Longifolia jack (E.L.) root extract on the serum leptin and testosterone levels of male rats. Methodology: Mature male Albino Wistar rats were used in this study. Serum leptin and testosterone ;levels were analyzed before receiving treatment (control group), then the rats were divided into two groups. Group A received 5mg/kg twice daily of pure E.L. root extract. Group B received 10mg/kg twice daily of the same extract. The duration of treatment was 6 weeks for both groups at the end of which, serum leptin and testosterone levels of both groups were analyzed again. Results: The mean serum leptin and testosterone levels for the control group were 1.13ng/ml, 0.79ng/ml. While for group A were1.08ng/ml, 0.98ng/ml and for Group B were 0.89ng/ml,1.75ng/ml respectively. Statistical analysis showed that the serum leptin level of group B was significantly lower than that of control group (p<0.001) and group A(p<0.05). On the other hand, no significant difference in serum leptin levels was observed between the control group and group A. The serum testosterone level was significantly higher in group B than control and group A while group A did not show a statistically significant difference than control. Conclusion: E.L. root extract can significantly decrease serum leptin and increase serum testosterone levels and these effects are dose dependant.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 6388/42547
Uncontrolled Keywords: testosterone hormones
Subjects: R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Depositing User: Assoc.Prof Ghasak Ghazi Al-Atrakchi
Date Deposited: 15 Jun 2015 16:05
Last Modified: 12 Dec 2018 12:13
URI: http://irep.iium.edu.my/id/eprint/42547

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