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Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: a review

Elgadir, M.Abd and Uddin, Md. Salim and Ferdosh, Sahena and Adam, Aishah and Khan Chowdhury, Ahmed Jalal and Sarker, Md. Zaidul Islam (2015) Impact of chitosan composites and chitosan nanoparticle composites on various drug delivery systems: a review. Journal of Food and Drug Analysis, 23 (4). pp. 619-629. ISSN 1021-9498

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Abstract

Chitosan is a promising biopolymer for drug delivery systems. Because of its beneficial properties, chitosan is widely used in biomedical and pharmaceutical fields. In this review, we summarize the physicochemical and drug delivery properties of chitosan, selected studies on utilization of chitosan and chitosan-based nanoparticle composites in various drug delivery systems, and selected studies on the application of chitosan films in both drug delivery and wound healing. Chitosan is considered the most important polysaccharide for various drug delivery purposes because of its cationic character and primary amino groups, which are responsible for its many properties such as mucoadhesion, controlled drug release, transfection, in situ gelation, and efflux pump inhibitory properties and permeation enhancement. This review can enhance our understanding of drug delivery systems particularly in cases where chitosan drug-loaded nanoparticles are applied.

Item Type: Article (Review)
Additional Information: 7165/40787
Uncontrolled Keywords: chitosan, drug delivery system, nanoparticle composite, wound healing
Subjects: R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Kulliyyah of Science > Department of Biotechnology
Kulliyyah of Science > Department of Plant Science
Depositing User: Professor Dr. Md. Zaidul Islam Sarker
Date Deposited: 03 Mar 2015 10:15
Last Modified: 29 Jan 2018 11:02
URI: http://irep.iium.edu.my/id/eprint/40787

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