IIUM Repository

Optimisation of the supercritical extraction of toxic elements in fish oil

Hajeb, Parvaneh and Jinap, S. and Shakibazadeh, Sh. and Afsah-Hejri, L. and Mohebbi, G.H. and Sarker, Md. Zaidul Islam (2014) Optimisation of the supercritical extraction of toxic elements in fish oil. Food Additives & Contaminants: Part A, 31 (10). pp. 1712-1722. ISSN 1944-0049

[img] PDF (Published paper)
Restricted to Repository staff only

Download (381kB) | Request a copy


This study aims to optimise the operating conditions for the supercritical fluid extraction (SFE) of toxic elements from fish oil. The SFE operating parameters of pressure, temperature, CO2 flow rate and extraction time were optimised using a central composite design (CCD) of response surface methodology (RSM). High coefficients of determination (R2 ) (0.897–0.988) for the predicted response surface models confirmed a satisfactory adjustment of the polynomial regression models with the operation conditions. The results showed that the linear and quadratic terms of pressure and temperature were the most significant (p < 0.05) variables affecting the overall responses. The optimum conditions for the simultaneous elimination of toxic elements comprised a pressure of 61 MPa, a temperature of 39.8ºC, a CO2 flow rate of 3.7 ml min−1 and an extraction time of 4 h. These optimised SFE conditions were able to produce fish oil with the contents of lead, cadmium, arsenic and mercury reduced by up to 98.3%, 96.1%, 94.9% and 93.7%, respectively. The fish oil extracted under the optimised SFE operating conditions was of good quality in terms of its fatty acid constituents.

Item Type: Article (Journal)
Additional Information: 6605/38953
Uncontrolled Keywords: fish oil; toxic elements; supercritical fluid extraction; optimisation
Subjects: Q Science > Q Science (General)
T Technology > T Technology (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Professor Md. Zaidul Islam Sarker
Date Deposited: 03 Nov 2014 09:05
Last Modified: 19 Jun 2018 14:31
URI: http://irep.iium.edu.my/id/eprint/38953

Actions (login required)

View Item View Item


Downloads per month over past year