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Changes in the markers of atherosclerosis following administration of Belimbing dayak (Baccaurea angulata) fruit juice in experimental rabbits fed with cholesterol diet

Mikail, Maryam Abimbola and Adewale, Ahmed Idris and Ibrahim, Muhammad and Hazali, Norazlanshah and Abdull Rasad, Mohammad Syaiful Baharii and Abdul Ghani, Radiah and Abdul Wahab, Ridhwan and Arief Ichwan, Solachuddin Jauhari and Md Isa, Muhammad Lokman and Draman, Samsul and Ishola, Afeez Adekunle and Adros Yahya, Mohammad Noor (2013) Changes in the markers of atherosclerosis following administration of Belimbing dayak (Baccaurea angulata) fruit juice in experimental rabbits fed with cholesterol diet. International Journal of Advances in Agricultural & Environmental Engineering (IJAEE), 1 (1). pp. 151-154. ISSN 2349-1523 (O), 2349-1523 (P)

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Abstract

The aims of this present study were to investigate the potential antioxidant, anti-inflammatory and plaque-reducing activity of Baccaurea angulata (BA) fruit as a new anti-atherogenic plant. Twenty five male rabbits of New Zealand strain used were randomly assigned to five groups. Rabbits were fed either a standard chow diet (group N) or a high-cholesterol diet (groups CH, C1, C2 and C3). Groups C1, C2 and C3 were also given 0.5ml or 1ml or 1.5ml/kg/day BA whole fruit juice respectively. BA juice had high antioxidant activities indicated by the increase in the SOD activity and total antioxidant capacity (TAC), when comparing the C1, C2 and C3 groups with group CH. In the group CH, there was statistically significant increase in IL-8 and IL-18 levels as compared to C1, C2 and C3 groups. Likewise, BA juice reduced plaque formation in rabbits’ aorta. Therefore, BA juice is beneficial in preventing atherosclerosis.

Item Type: Article (Journal)
Additional Information: 4998/38821
Uncontrolled Keywords: Antioxidant, anti-inflammatory, atherosclerosis, Baccaurea angulata
Subjects: R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Depositing User: Muhammad Ibrahim
Date Deposited: 17 Oct 2014 11:22
Last Modified: 27 Nov 2014 16:31
URI: http://irep.iium.edu.my/id/eprint/38821

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