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Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes

Azahari, Nuraniza and Khattak, Muhammad Muzaffar Ali Khan and Bakhtiar, M. Taher and Arief Ichwan, Solachuddin Jauhari (2014) Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes. Journal of Food and Nutrition Research, 2 (11). pp. 764-769. ISSN 13368672

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Abstract

Cinnamon is a common spice which is widely advocated for its efficacy controlling of hyperglycemia. However, the mechanism of action has yet to be established for the effect on the blood glucose concentration. Cinnamon was extracted with water and induced to cell line namely 3T3-L1 preadipocyte (American Type cell Culture Collection). The cell proliferation, differentiation (adipogenesis) and glucose uptake activity were assessed by measuring the uptake of radio-labelled glucose. Furthermore, for comparison glucose oxidase assay was also performed by using Glucose Assay Kit (Sigma-Aldrich, Inc). The collected data was statistically analysed using SPSS version 12.0 for any possible differences. This study revealed that there was a significant (P<0.01) increase the activity/adipogenesis. This increase activity was accompanied by significant (P<0.01) increase in the glucose uptake and reduced catalytic activity of lipids (lipolysis). The finding reveals that C. Zeylanicum extract has similar effect to that of insulin activity. The present study suggests that the cinnamon enhances glucose uptakes, reduces the lipid breakdown and resembles insulin activity.

Item Type: Article (Journal)
Additional Information: 5304/38810
Uncontrolled Keywords: cinnamon, 3T3-L1 adipocytes, adipogenesis, glucose uptake, glucose oxidase
Subjects: T Technology > TX Home economics
T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Kulliyyah of Dentistry
Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Muhammad Muzaffar Ali Khan Khattak
Date Deposited: 16 Oct 2014 12:17
Last Modified: 12 Jun 2018 09:16
URI: http://irep.iium.edu.my/id/eprint/38810

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