QSAR study of platelet-activating factor (PAF) receptor binding antagonist

Abdullah, Nor Hayati and Ibrahim Ali , Noorbatcha and Ling, Sui Kiong (2013) QSAR study of platelet-activating factor (PAF) receptor binding antagonist. In: International Conference on Biotechnology Engineering (ICBioE 2013), 2 – 4 Jul 2013, Kuala Lumpur, Malaysia.

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Abstract

The aim of this study was to find the structure activity relationship between the platelet-activating factor (PAF) receptor binding antagonist activity and the psychochemical properties of flavonoids 1-11 by using quantum chemical QSAR approach. The semi-empirical method quantum method was used to optimize the molecular structures of the flavanoids and various quantum chemical descriptors were calculated from the optimized structures. Heuristic and multi-linear regression methods were used to determine the correlation between the quantum chemical properties and the experimental PAF receptor binding inhibitory activity. The best correlation equation was obtained using three descriptors and multi-linear correlation method with R2= 0.9632

Item Type:	Conference or Workshop Item (Full Paper)
Additional Information:	3704/34147
Uncontrolled Keywords:	QSAR, PAF, flavonoids, semi-empirical
Subjects:	T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof. Dr. Ibrahim Ali Noorbatcha
Date Deposited:	15 Jan 2014 10:45
Last Modified:	15 Jan 2014 10:45
URI:	http://irep.iium.edu.my/id/eprint/34147

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