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The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney

Al-Ani, Imad Matloub Dally and Al-Murayati, H.Y. and Ghani, H.M. (2011) The effect of Proteus mirabilis isolated from human urinary tract infections on the morphology of the rat kidney. In: 2nd Malaysian Anatomical Conference, 8-9 June 2011, Shah Alam, Selangor. (Unpublished)

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Abstract

Proteus mirabilis has previously been shown to be capable of persisting in the rat kidney for up to 8 weeks and induces many physiological changes following a single inoculation of the urinary bladder. The present study examined kidney tissue from infected animals for evidence of renal damage.The earliest histologic changes seen on the 2nd and 4th days, consisted of mild cellular sloughing and edema associated with mononuclear infiltration in the medulla and to a lesser extent in the cortex. On the 1st and following weeks, tubular atrophy, interstitial fibrosis, and a mononuclear infiltrate had advanced in the renal parenchyma re-sulting in chronic pyelonephritis. The observed renal degenerations with a corresponding ascending bacterial infection in the intra-renal reflux suggest that Proteus mirabilis is capable of producing chronic pyelonephritis in the rats after a single reflux challenge. Key Words: Kidney, Proteus mirabilis, Pyelonephritis, Rats, Urinary tract.

Item Type: Conference or Workshop Item (Full Paper)
Additional Information: 5849/33496
Subjects: Q Science > QM Human anatomy
Q Science > QP Physiology
Q Science > QR Microbiology
R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited: 15 Jan 2014 15:42
Last Modified: 18 Dec 2015 10:48
URI: http://irep.iium.edu.my/id/eprint/33496

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