Assessment of cytotoxicity and toxicity for phosphonium-based deep eutectic solvents

Hayyan, Maan and Hashim, Mohd. Ali and Al-Saadi, Mohammed A. and Hayyan, Adeeb and Alnashef, Inas Muen and Mirghani, Mohamed Elwathig Saeed (2013) Assessment of cytotoxicity and toxicity for phosphonium-based deep eutectic solvents. Chemosphere, 93 (2). pp. 455-459. ISSN 0045-6535

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Abstract

In this work, the cytotoxicity and toxicity of phosphonium-based deep eutectic solvents (DESs) with three hydrogen bond donors, namely glycerine, ethylene glycol, and triethylene glycol were investigated. The cytotoxicity effect was tested using brine shrimp (Artemia salina). The toxicity was investigated using the two Gram positive bacteria Bacillus subtilis and Staphylococcus aureus, and two Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. The cytotoxicity of tested DESs was much higher than that of their individual components, indicating their toxicological behavior was different. It was also found that there was toxic effect on the studied bacteria, indicating their potential application as anti-bacterial agents. To the best of our knowledge, this is the first time the cytotoxicity and toxicity of phosphoniumbased DESs were studied.

Item Type:	Article (Journal)
Additional Information:	4971/32301
Uncontrolled Keywords:	Deep eutectic solvent, Ionic liquid, Cytotoxicity, Toxicity, Anti-bacteria, Brine shrimp
Subjects:	T Technology > T Technology (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	A Prof Elwathig Mirghani
Date Deposited:	11 Oct 2013 16:36
Last Modified:	16 Mar 2015 10:29
URI:	http://irep.iium.edu.my/id/eprint/32301

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