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Are deep eutectic solvents benign or toxic?

Hayyan, Maan and Hashim, Mohd Ali and Hayyan, Adeeb and Al-Saadi, Mohammed A. and Alnashef, Inas Muen and Mirghani, Mohamed Elwathig Saeed and Saheed, Olorunnisola Kola (2013) Are deep eutectic solvents benign or toxic? Chemosphere, 90 (7). pp. 2193-2195. ISSN 0045-6535

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Abstract

In continuation of investigation for environmentally benign protocol for new solvents termed deep eutectic solvents (DESs), it is herein reported results concerning the toxicity and cytotoxicity of choline chloride (ChCl) based DESs with four hydrogen bond donors including glycerine, ethylene glycol, triethylene glycol and urea. The toxicity was investigated using two Gram positive bacteria Bacillus subtilis and Staphylococcus aureus, and two Gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. The cytotoxicity effect was tested using the Artemia salina leach. It was found that there was no toxic effect for the tested DESs on all of the studied bacteria confirming their benign effects on these bacteria. Nevertheless, it was found that the cytotoxicity of DESs was much higher than their individual components (e.g. glycerine, ChCl) indicating that their toxicological behavior is different. For our best knowledge this is the first time that toxicity and cytotoxicity of DESs were studied. The toxicity and cytotoxicity of DESs varied depending on the structure of components. Careful usage of the terms non-toxicity and biodegradability must be considered. More investigation on this matter is required.

Item Type: Article (Journal)
Additional Information: 4971/29509
Uncontrolled Keywords: Deep eutectic solvent; Toxicity; Cytotoxicity; Ionic liquid Synergetic effect; Brine shrimp
Subjects: T Technology > TD Environmental technology. Sanitary engineering
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Assoc Prof Elwathig Mirghani
Date Deposited: 04 Apr 2013 08:30
Last Modified: 27 May 2013 06:24
URI: http://irep.iium.edu.my/id/eprint/29509

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