β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications

Md. Badruddoza , Abu Zayed and Rahman , Md. Taifur and Ghosh , Sudipa and Hossain , Md. Zakir and Shi , Jizhong and Hidajat , Kus and Uddin, Mohammad Shahab (2013) β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications. Carbohydrate Polymers, 95 (1). pp. 449-457. ISSN 0144-8617 (O)

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Abstract

We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe 3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery.

Item Type:	Article (Journal)
Additional Information:	6814/29307
Uncontrolled Keywords:	β-Cyclodextrin; Cell targeting; Fluorescent imaging; Hydrophobic drug inclusion; Multifunctional magnetic nanoparticles
Subjects:	T Technology > TP Chemical technology > TP155 Chemical engineering T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Professor Mohammad Shahab Uddin
Date Deposited:	19 Aug 2013 13:20
Last Modified:	14 Feb 2014 11:05
URI:	http://irep.iium.edu.my/id/eprint/29307

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