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Process modelling and debottlenecking study of a vaccine production

Mohamed Safri, Nurul Huda and Mel, Maizirwan and Foo, Dominic Chwan Yee and K.S. Ng, Denny and M.L. Chew, Irene (2012) Process modelling and debottlenecking study of a vaccine production. IIUM Engineering Journal, 13 (1). pp. 97-107. ISSN 1511-788X

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The main objective of this work is to model and optimise a locallydeveloped Infectious Coryza (IC) vaccine production. The simulation work is performed using a commercial batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost to benefit ratio (CBR) when the annual production is increased by 100%. Based on the economic analysis, the selected debottlenecking scheme has annual revenue of USD 240 million, with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition, the payback period of the selected scheme is estimated to be within three years.

Item Type: Article (Journal)
Additional Information: 4085/25806
Uncontrolled Keywords: process simulation; modelling; debottlenecking; optimisation
Subjects: T Technology > TP Chemical technology > TP155 Chemical engineering
T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Dr Maizirwan Mel
Date Deposited: 25 Oct 2012 09:33
Last Modified: 25 Oct 2012 09:33
URI: http://irep.iium.edu.my/id/eprint/25806

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