Fowl cholera vaccine production: process optimization in laboratory scale fermenter

Mel, Maizirwan and Abdul Karim, Mohamed Ismail and Yob, Nor Jannah and Samsury, Intan Zahrah and Syed Hassan, Sharifah and Ngah Hamid, Akma (2011) Fowl cholera vaccine production: process optimization in laboratory scale fermenter. In: Current research and development in biotechnology engineering at IIUM (Volume III). IIUM Press, Kuala Lumpur, pp. 147-158. ISBN 9789674181444

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Abstract

The process optimization of Pasteurella multocida fermentation for fowl cholera vaccine production in 2L laboratory scale fermenter was successfully carried out in stirred tank reactor (STR). This study focuses on the maximizing the cell growth and protein production of P. multocida by optimizing process of various fermentation condition. The process optimization was designed for different level of parameters that were dissolved oxygen concentration (pO2), stirred speed (rpm)and pH using Taguchi's Experimental Robust Design by STATISTICA 6.0 agitation (200 rpm) and for antigen protein production was significantly affected by higher level (1 vvm). The correlation between the parameters was very affecting the productivity of the vaccine produced.

Item Type:	Book Chapter
Additional Information:	4085/25081
Uncontrolled Keywords:	fowl cholera vaccine, media, shake flask culture
Subjects:	T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Sakinah Kamaludin
Date Deposited:	24 Jul 2012 13:17
Last Modified:	24 Jul 2012 13:17
URI:	http://irep.iium.edu.my/id/eprint/25081

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