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Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors

Ibrahim Ali , Noorbatcha and Wan Norulhazrina, Wan Hassan and Maizirwan , Mel (2011) Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors. In: Bioprocessing of Recombinant E. Coli producing beta-glucuronidase enzyme. IIUM Press, Kuala Lumpur, Malaysia, pp. 115-123. ISBN 9789674180102

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ABSTRACT The chapter focuses on the growth kinetics and modelling of recombinant Escherichia coli in fermentation processes. Experimental data for from four bioreactors were analyzed using Monod, Logistic and Contois models. A comparison between the models' predicted values of cell, substrate and product (β-glucuronidase enzyme) was done with the kinetic parameters mmax, YX/S, Ks, k1, and k2 calculated from the experimental data. Substrate used for this modelling was glucose while the independent variables were peptone soy, sodium chloride and yeast extract. The Logistic model is found to describe the growth of E. coli in the fermentation process with the limited supply of glucose and the Monod and Contois models failed to represent the cell growth profiles. Keywords: growth kinetics, modeling, recombinant E. coli, fermentation.

Item Type: Book Chapter
Additional Information: 3704/24222
Uncontrolled Keywords: Growth kinetics, Escherichia coli
Subjects: T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Prof. Dr. Ibrahim Ali Noorbatcha
Date Deposited: 07 Aug 2012 14:05
Last Modified: 07 Aug 2012 14:21
URI: http://irep.iium.edu.my/id/eprint/24222

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