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Determination of octanol-water partition coefficients of anti-microbial alkaloids from Glycosmis pentaphylla (Retz) DC

Ahmad, Kausar and Mohd. Hassan, Norazian and Helaluddin , Abul Bashar Mohammed and Mat Ali, Idura and Mansor, Norhafizah (2010) Determination of octanol-water partition coefficients of anti-microbial alkaloids from Glycosmis pentaphylla (Retz) DC. In: 3rd International Conference on Advancement in Science and Technology (iCAST) 2010, 27-29 November 2010, Vistana Hotel, Kuantan, Pahang.

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Abstract

Octanol-water partition coefficient (KOW) values of anti-microbial alkaloids, arborine and arborinine of Glycosmis pentaphylla (Retz) DC were determined. The method of extraction by solvents of these alkaloids and the following isolation procedures using column chromatography techniques will adopt those ascertained and established earlier (Norazian, 2006). A shake-flask method was used to determine the octanol-water partition coefficients from (298.15, 303.15, 308.15 and 313.15)k. Each compound was dissolved in the octanol to a known concentration and placed in octanol-water system and allowed to equilibrate. The concentration in the octanol phase was then determined by using spectrophotometer. The KOW was calculated as the ratio of the concentration in octanol phase to the concentration in aqueous phase.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 4551/21201
Uncontrolled Keywords: octanol-water partition
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User: DR KAUSAR AHMAD
Date Deposited: 17 Jul 2013 09:16
Last Modified: 17 Jul 2013 09:17
URI: http://irep.iium.edu.my/id/eprint/21201

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