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Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology

Bimakr, Mandana and Abdul Rahman, Russly and Ganjloo, Ali and Taip, Farah Saleena and Md Salleh, Liza and Sarker, Md. Zaidul Islam (2012) Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology. Food and Bioprocess Technology, 5 (3). pp. 912-920. ISSN 1935-5130

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Abstract

The bioactive flavonoid compounds of spearmint (Mentha spicata L.) leaves were obtained by using supercritical carbon dioxide (SC-CO2) extraction. Extraction was carried out according to face-centred central composite design, and independent variables were pressure (100, 200 and 300 bar), temperature (40, 50 and 60 °C) and co-solvent amount (3, 6 and 9 g/min). The extraction process was optimized by using response surface methodology for the highest crude extraction yield of bioactive flavonoid compounds. The optimal conditions were identified as 209.39 bar pressure, 50.00 °C temperature and 7.39 g/min co-solvent amount. The obtained extract under optimum SC-CO2 condition was analysed by high-performance liquid chromatography. Seven bioactive flavonoids including catechin, epicatechin, rutin, luteolin, myricetin, apigenin and naringenin were identified as major compounds. The results of quantification showed that spearmint leaves are potential source of antioxidant compounds.

Item Type: Article (Journal)
Additional Information: 6605/17932
Uncontrolled Keywords: Spearmint (Mentha spicata L.,Supercritical carbon dioxide (SC-CO2) extraction,Response surface methodology, Bioactive flavonoid compounds, HPLC
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Professor Dr. Md. Zaidul Islam Sarker
Date Deposited: 14 Feb 2012 09:22
Last Modified: 15 Dec 2016 15:13
URI: http://irep.iium.edu.my/id/eprint/17932

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