Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants

Jamal, Parveen and Azmi, Saiful Mohammad Nizam and Amid, Azura (2010) Screening of Xanthine Oxidase inhibitor from potential Malaysian medicinal plants. In: UMT 9th International Annual Symposium on Sustainability Science and Management (UMTAS 2010), 8 - 11 May 2010, Terengganu, Malaysia.

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Abstract

Malaysia has a rich diversity of medicinal plants and some of them are believed to have the property to inhibit xanthine oxidase activity, which can be introduced as a new natural source of gout medication and a substitute for synthetic xanthine oxidase inhibitors (XOI). In this study, forty two samples from seventeen plant species were examined for xanthine oxidase inhibitory activity. Selection of plants was based on their frequent usages by local folks for their medicinal benefits and their activity in three different extraction solvents. The degree of XO inhibition was determined by measuring the absorbance spectrophotometrically at 295 nm associated with uric acid formation. Ninety-nine percent of the crude extracts were found to have XO inhibitory activity at 100 μg/ml, and 59% showed greater than 50% inhibition. The ripe fruit peels of Garcinia mangostana L. has the potential to be exploited as an alternative to allopurinol as the crude extracts of this plant material from all three solvents, namely, 70% methanol, ethanol and distilled water, exhibited the highest XOI activity with 88.74%, 84.69% and 80.18% inhibition, respectively. The ripe fruit peels of Cucumis sativus and the leaves of Morinda citrifolia can also be considered as potential alternatives to allopurinol as they have demonstrated the second and third highest XOI activity especially with 70% methanol as the extraction solvent.

Item Type:	Conference or Workshop Item (Full Paper)
Additional Information:	2937/16828
Uncontrolled Keywords:	Garcinia mangostana L., medicinal plants, screening, xanthine oxidase inhibitor
Subjects:	T Technology > TA Engineering (General). Civil engineering (General) > TA164 Bioengineering T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof.Dr. Parveen Jamal
Date Deposited:	27 Jan 2012 11:04
Last Modified:	25 Jul 2012 07:41
URI:	http://irep.iium.edu.my/id/eprint/16828

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