Cytotoxic effects of Salvia officinalis extraction MCF-7 human breast cancer cells

Sama, Naziyah Shaban and Solachuddin Jauhari, Arief Ichwan and Mustafa Al-Ahmad, Basma Ezzat and Mokhtar@Makhtar, Khairani Idah and Khalil, Raida (2026) Cytotoxic effects of Salvia officinalis extraction MCF-7 human breast cancer cells. Karsaz Journal of Applied Innovation in Science & Engineering, 1. pp. 22-24.

PDF - Published Version Restricted to Registered users only Download (413kB) | Request a copy

Abstract

Salvia officinalis (sage) is a medicinal plant recognized for its antioxidant and potential anticancer properties. This study has been designed to assess the cytotoxic properties of sage plant on human breast cancer cells (MCF-7). MCF-7cells were treated with variable concentrations of sage extract, and cell viability was evaluated by means of the MTT assay. The results showed a dose-dependent reduction in cell viability, the highest extract concentration reducing viability by approximately 60%. The estimated IC₅₀ value indicated moderate cytotoxic potency. These findings suggest that Salvia officinalis contains bioactive compounds capable of inhibiting breast cancer cell proliferation. Further studies are recommended to explain the underlying mechanisms and assess its healing potential in-vivo.

Item Type:	Article (Journal)
Additional Information:	Newly established academic journal that has not yet been assigned an official ISSN - 15/7/2026 NS
Uncontrolled Keywords:	MCF-7, Breast cancer, Salvia officinallis, Cytotoxicity.
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Dr Basma Al-Ahmad
Date Deposited:	15 Jul 2026 20:57
Last Update:	15 Jul 2026 20:57
Queue Number:	2026-07-Q4179
URI:	http://irep.iium.edu.my/id/eprint/130078

Actions (login required)

View Item