Candida auris in oral biofilms: implications for chronic inflammation, oral carcinogenic potential and natural therapeutics

Jaafar, Aisyah and Mohd Hussaini, Haizal and Arzmi, Mohd Hafiz and Zainal, Mukarramah (2026) Candida auris in oral biofilms: implications for chronic inflammation, oral carcinogenic potential and natural therapeutics. In: COMPILATION OF RESEARCH PAPERS ON STEM, JUNE 2026. MNNF Publisher, Negeri Sembilan, pp. 73-79. ISBN 9789670052236

PDF - Published Version Restricted to Repository staff only Download (1MB) | Request a copy

Abstract

Candidozyma auris (Candida auris) is a multidrug-resistant fungal pathogen commonly associated with nosocomial infections and causes significant morbidity globally. Although direct evidence linking C. auris in oral infection and oral squamous cell carcinoma (OSCC) remains limited, its biofilm-forming and host response modulating ability suggests a potential role in creating a pro-inflammatory microenvironment, that favours disease progression. The increasing prevalence of antifungal-resistant C. auris strains has encouraged the search for alternative therapeutic approaches. Natural products including plant-derived bioactive compounds and essential oils have demonstrated promising antifungal and antibiofilm activities against C. auris. Nonetheless, their specific mechanisms of action in inhibiting fungal growth and biofilm formation remains to be elucidated in future studies. This review explores the pathogenic role of C. auris in oral biofilms, its implications for chronic inflammation-induced oral carcinogenesis, and the emerging use of natural products as alternative therapeutic strategies against this challenging fungal pathogen.

Item Type:	Book Chapter
Uncontrolled Keywords:	Candidozyma auris, oral biofilms, chronic inflammation, oral carcinogenesis, natural therapeutics
Subjects:	Q Science > QR Microbiology R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Prof Ts Dr Mohd Hafiz Arzmi
Date Deposited:	23 Jul 2026 16:39
Last Update:	23 Jul 2026 16:39
Queue Number:	2026-07-Q4117
URI:	http://irep.iium.edu.my/id/eprint/130002

Actions (login required)

View Item