Serum biomarkers as personalised medicine for diagnostic and therapeutic approaches of hepatocellular carcinoma

Bakhtiar, M. Taher and Muhamad Asri, Muhamad Aqil Ikram and Abdul Rahman, Nur Damia and Zamzuri, Nur Eleisha and Muhammad Faizal, Nur Syazwani and Khotib, Junaidi and Darnis, Deny Susanti and Hasdan, Nurul Athirah and Haris, Muhammad Salahuddin and Rakhmawati, Rita (2026) Serum biomarkers as personalised medicine for diagnostic and therapeutic approaches of hepatocellular carcinoma. Journal of the Egyptian National Cancer Institute, 38 (7). pp. 1-11. ISSN 1110-0362 E-ISSN 2589-0409

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Abstract

Hepatocellular carcinoma (HCC) is a critical public health concern due to its rising incidence and mortality. Early diagnosis is challenging due to nonspecific symptoms and limitations of traditional methods. This study explores the potential of three key biomarkers, serum alpha-fetoprotein (AFP), des-γ-carboxyprothrombin (DCP), and glypican-3 (GPC3), in advancing personalized medicine for HCC, focusing on their roles in diagnostics and therapeutics. We conducted a literature review using specific keywords to narrow our search. Our findings indicate that AFP and DCP are primarily used for diagnostics, while GPC3 serves both diagnostic and therapeutic purposes. AFP is commonly used in late-stage detection due to its limited sensitivity and specificity in early stages, which can lead to false diagnoses. DCP plays a significant role as both a diagnostic tool and therapeutic target, while GPC3 is used to differentiate malignant from non-cancerous liver tissues. The review highlights the mechanisms, roles, and personalised treatments associated with these biomarkers, while also addressing challenges such as biopsy issues and funding limitations. In conclusion, the development and improvement of AFP, DCP, and GPC3 as biomarkers for the diagnostics and treatment of HCC are important. Thus, their limitations should be addressed as these biomarkers play a crucial role in modern cancer therapy and are critical for increasing the survival rates of HCC patients.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Hepatocellular carcinoma, Serum biomarkers, Diagnostic, Therapeutic, Alpha fetoprotein, Des-γ-carboxyprothrombin, Glypican-3
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	10 Mar 2026 15:13
Last Modified:	10 Mar 2026 15:13
Queue Number:	2026-03-Q2522
URI:	http://irep.iium.edu.my/id/eprint/127863

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