Ahmad Affandi, Khairunisa and Hamdan, Asmah Hanim and Abd. Fuaat, Azliana and A. Talib, Noorlelawati and Abdul Halim, Sarah (2025) Prevalence of HPV 16/18 positivity and cytological findings in the post-vaccination era: a retrospective study at SASMEC@IIUM. In: International Academy of Pathology Malaysian Division (IAPMD) 10th Annual Scientific Meeting 2025, Breast & Gynaecology Pathology: Empowering Women’s Health, From Cells to Cure, 1-2 October 2025, SunMed Convention Centre, Sunway Medical Centre, Selangor, Malaysia.
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Abstract
Introduction: Malaysia’s national HPV vaccination program was introduced over a decade ago to reduce cervical cancer rates. As vaccinated cohorts enter screening age, evaluating the local prevalence of HPV 16/18 is essential to assess vaccine impact and guide screening practices. Cytology remains central to cervical screening, but may not detect all high-risk infections. This study aims to determine the prevalence of HPV 16/18 among HPV-positive women at SASMEC@IIUM and examine their correlation with cytological findings. Materials and Methods: A retrospective cross-sectional review of medical records was conducted for 304 HPV-positive women screened between 2019 and 2024. Data extracted included age, HPV genotype, and Pap smear results. Cases positive for HPV 16 and/or 18 were categorised using the Bethesda System. Results: The median age was 35 years (range: 19-64). HPV 16 and/or 18 were detected in 51 cases (16.8%): 17 (5.6%) with HPV 16 alone, 19 (6.3%) with HPV 18 alone, and 15 (4.9%) with both. Among these, 26 (51%) had negative cytology, while 17 (33.3%) showed epithelial abnormalities, indicating genotype–cytology discordance. Discussion and Conclusion: HPV 16/18 remains detectable in the post-vaccination era, with over half of positive cases showing negative cytology. These findings support the incorporation of HPV genotyping into routine screening and highlight the need for continued local monitoring.
| Item Type: | Proceeding Paper (Poster) |
|---|---|
| Uncontrolled Keywords: | cervical cancer; cervical cytology; HPV; HPV vaccination |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RB Pathology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Pathology & Lab Medicine |
| Depositing User: | Dr Khairunisa Ahmad Affandi |
| Date Deposited: | 06 Mar 2026 15:55 |
| Last Modified: | 06 Mar 2026 15:55 |
| Queue Number: | 2026-03-Q2446 |
| URI: | http://irep.iium.edu.my/id/eprint/127788 |
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