Aljarousha, Mohammed and Beshtawi, Ithar and Alghamdi, Waleed M. and Badarudin, Noor Ezailina and Che Azemin, Mohd Zulfaezal and Abdul Rahim, Muhammad Afzam Shah and Awg Isa, Mohd Zaki and Mohd Nordin, Fairuz and Naes, Safaa M. and Shaqoura, Emad IH and Ismail, Siti 'Aishah and Azman, Nahdiyah and Attaallah, Sara and Alhoot, Mohammed Abdelfatah and Celebi, Ali Riza Cenk (2026) Efficacy of 0.38% and 0.18% sodium hyaluronate ocular lubricants for dry eye: a randomized trial in adult gazan participants. Journal of Optometry, 19 (1). pp. 1-10. ISSN 1888-4296
|
PDF
- Published Version
Download (586kB) | Preview |
|
|
PDF (Scopus)
- Supplemental Material
Download (243kB) | Preview |
|
|
PDF
- Supplemental Material
Download (442kB) | Preview |
Abstract
Purpose: This study aimed to assess the efficacy of two formulations of lubricant eye drops, containing a gelling agent or not, compared to normal saline. This was a prospective, randomized, double-blinded, three-group, parallel, interventional single-site clinical study. Methods: Forty-five Gazan participants with moderate to severe dry eye disease (DED) were randomized into three groups of 15 participants each. Each group received either normal saline eye drops or lubricant eye drops. For each group, one drop was applied three times a day for six weeks. All participants applied the normal saline solution for the first week. The outcomes assessed were the Arab-ocular surface disease index (Arab-OSDI) scores and clinical tests including tear break-up time test (TBUT), corneal fluorescein staining (CFS), and lissamine green conjunctival staining (LGS) at weeks 1, 3, and 6. Results: Both formulations exhibited a significant improvement in Arab-OSDI scores from visit 2 at follow-up time points (p < 0.001). TBUT, CFS, and LGS showed an improvement in both the SH 0.15% and SH 0.38% groups (p < 0.05). SH 0.38% had a greater improvement in the proportion of evaporative dry eye from visit 2 to visit 5 (p = 0.001). Conclusion: Lubricant eye drops are beneficial for alleviating the symptoms of dry eye. There was no noticeable difference in the effectiveness of these formulations in relieving symptoms and changing any of the objective signs that were assessed. Improved EDE outcomes occurred with SH 0.38% eye drops, observed between visit 2 and visit 5.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | Lubricant eye drops Gazan participants SH 0.15% SH 0.38% interventional single-site clinical study dry eye disease |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RE Ophthalmology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Optometry and Visual Science |
| Depositing User: | Dr. Mohd Zulfaezal Che Azemin |
| Date Deposited: | 11 Feb 2026 11:14 |
| Last Modified: | 11 Feb 2026 11:14 |
| Queue Number: | 2026-02-Q2048 |
| URI: | http://irep.iium.edu.my/id/eprint/127307 |
Actions (login required)
 |
View Item |
Download Statistics
Download Statistics