Bioactivities of a-mangostin from Garcinia malaccensis Hk.f

Zohri, Farah Syahidah A and Bakhtiar, M. Taher and Darnis, Deny Susanti and Nakazibwe, Sauba and Solachuddin Jauhari, Arief Ichwan (2010) Bioactivities of a-mangostin from Garcinia malaccensis Hk.f. In: International Conference on Advancement in Science and Technology (iCAST2010): The Science of Traditional Practices in Health and Disease, 26-29 Nov 2010, Kuantan, Malaysia. (Unpublished)

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Abstract

Guttiferae family is well known to have a wide range of phytochemical sontituents and bioactivities. A phytochemical investigation of Garcinia malaccensis leasd isolaton of a-mangostin, b-mangostin and a triterpenoid. a-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of a-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of a-mangostin. Its structural determination was done based on its spectroscopic analysis. a-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S.aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MBC)value was 0.1mg/mL, indicted that a-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of a-mangostin. In FTC method, a-mangosin was proved to be good lipid peroxidation inhibitor, whereas in DPPH free redical scevenging activity method, it has very weak scavening effects on free radicals. In antiproliferative assay, a-mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20ug/mL. This study can form a foundation for future studies in investigating of biological activities of-amangostin and developing the natural abundant in improving a healthy community.

Item Type:	Conference or Workshop Item (Lecture)
Additional Information:	5641/12148
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biomedical Science
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	17 Jan 2012 11:06
Last Modified:	09 Dec 2014 09:37
URI:	http://irep.iium.edu.my/id/eprint/12148

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