Antimicrobial compounds from Calophyllum canum

Sheikh, Hasan I and Darnis, Deny Susanti and Bakhtiar, M. Taher and Ahmed, Hanad and Syed Osman Idid, Syed Zahir Idid (2010) Antimicrobial compounds from Calophyllum canum. In: International Conference on Advancement in Science and Technology (iCAST2010): The Science of Traditional Practices in Health and Disease, 26-29 Nov 2010, Kuantan, Malaysia.

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Abstract

Calophyllum species have been used in traditional medicine for its therapeutic properties in many tropical climate counteries. Calopyllum canum locally known as bintagor merah has been isolated and tested for its antimcirobial activity. Stembarks of C. canum were extracted by soxhlet extraction with n-hexane, ethyl acetate and then methanol, successively. The antimictovial activity was carried out by disc difussion method and determination of MIC and MBC values. n-Hexane extracts was active against S.aureus and B.subtili, while methanol extract inhibited the growuth of S.aureus, B.subtilis and E.coli. Ethyl acetate extract was also active against S.aureus and B.subtilis. Both n-haxena and methanol extracts were furhter subjected to column chramotography by guiding of its antimicrobial actvity. Four compounds were sucesfully isolated.; two (D1 and D2) from n-hexane extract and two from methanol (CCM1 and CCM2). The compondsD1 and d2 were active against S.aureus and B. anthracis. While CCM1 and CCM2 were active against S.aureus. Furhter research need to be done to identify the structure of the active compounds and investigate their mood of action.

Item Type:	Conference or Workshop Item (Lecture)
Additional Information:	5641/12137
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Science > Department of Biotechnology
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	16 Jan 2012 16:17
Last Modified:	09 Dec 2014 09:35
URI:	http://irep.iium.edu.my/id/eprint/12137

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