Study of cytotoxic activities of Rubraxanthone

Bakhtiar, M. Taher and Sawaneh, Fatoumata and Darnis, Deny Susanti (2009) Study of cytotoxic activities of Rubraxanthone. In: Bandung International Conference on Medicinal Chemistry, 6-8 August 2009, Bandung, Indonesia.

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Abstract

Rubraxanthone is a prenylated xanthone that was isolated from Garcinia euginifolia (Guttiferae). It is having antimicrobial and antiplatelet activating factor activities. The research is aimed to study a cytotoxic activity of the compound by using in vitro cell culture technique. In order to evaluate the activity against cancer, the compound is exposed for its activity against several cancerous cell lines. It is tested against breast (MCF-7), bone (Saos-2), cervix (SiHa and C33A), colorectal (HCT-116), esophageal (TE1 and TE2), rectum (SW837) cancer cells and normal fibroblast (NHDF). The cells were seeded in a 96-well plate a density of 2 x 10^5 cells/mL. The compound is being tested to confluent celss for two days. Antiproliverative activity is evaluated by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazoliumbromide) (MTT) assay. It is found that the compound exhibits a moderate activity against all type of the cells.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5209/12122
Uncontrolled Keywords:	Rubraxanthone, cytotoxic activities, cancer, cell liners
Subjects:	Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Biomedical Science
Depositing User:	Dr Deny Susanti Darnis
Date Deposited:	26 Jan 2012 16:24
Last Modified:	09 Dec 2014 09:42
URI:	http://irep.iium.edu.my/id/eprint/12122

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