Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages

Rullah, Kamal and Shamsudin, Nur Farisya and Koeberle, Andreas and Tham, Chau Ling and Mohd Aluwi, Mohd Fadhlizil Fasihi and Leong, Sze Wei and Jantan, Ibrahim and Lam, Kok Wai (2024) Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages. Future Medicinal Chemistry, 16 (1). pp. 75-99. ISSN 1756-8927

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Abstract

Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targeting MD-2, IκB kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression.

Item Type:	Article (Review)
Uncontrolled Keywords:	flavonoids • inflammatory responses • lipopolysaccharides • macrophages • monocytes
Subjects:	R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy
Depositing User:	Dr Kamal Rullah
Date Deposited:	18 Dec 2024 08:17
Last Modified:	18 Dec 2024 08:17
URI:	http://irep.iium.edu.my/id/eprint/116793

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