Chemical composition and cytotoxicity of Garcinia urophylla Scort. ex King essential oil

Adward, Keith Katrina and Wan Salleh, Wan Mohd Nuzul Hakimi and Salihu, Abubakar Siddiq and Ab Ghani, Nurunajah and Arzmi, Mohd Hafiz and Khamis, Shamsul (2024) Chemical composition and cytotoxicity of Garcinia urophylla Scort. ex King essential oil. Rivista Italiana delle Sostanze Grasse, 101 (1). pp. 45-49. ISSN 0035-6808

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Abstract

Essential oils, a volatile mixture derived from plants, have shown a wide biological activity, and have been used as ancient remedies for the treatment of various diseases. The objective of this study was to investigate the chemical composition and cytotoxicity of the essential oil obtained from Garcinia urophylla leaves collected from Malaysia. Eighteen components were identified using gas chromatography-flame ionisation detection (GC- FID) and gas chromatography/mass spectrometry (GC-MS), which represent 99.9% of the essential oil. The major components were β-caryophyllene (56.2%), α-humulene (26.3%), and α-gurjunene (6.3%). The cytotoxicity of essential oil was evaluated using an MTT assay. The essential oil exhibited cytotoxicity against three cancer cell lines which are HepG2, MCF7, and A549 with the IC50 values of 71.5, 56.2, and 68.5 μg/ mL, respectively. To the best of our knowledge, this is the first report on the essential oil composition obtained from Garcinia urophylla, which may have implications on the pharmaceutical and therapeutic applications of Garcinia genus essential oils.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Essential oil; Garcinia urophylla; β-caryophyllene; cytotoxicity
Subjects:	Q Science > QK Botany
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	23 Apr 2024 11:50
Last Modified:	30 Apr 2024 16:34
URI:	http://irep.iium.edu.my/id/eprint/111864

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