The role of treponema denticola in the periodontitis alveolar bone damage: a systematic review

Idrus, Erik and Hartanto, Willy and Lestari, Widya and Suniarti, Dewi Fatma (2023) The role of treponema denticola in the periodontitis alveolar bone damage: a systematic review. Odonto Dental Journal, 10 (2). pp. 314-325. ISSN 2354-5992 E-ISSN 2460-4119

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Abstract

ABSTRACT Background: Periodontitis is a chronic inflammation condition of the periodontal tissue, which causes irreversible, progressive deterioration of the tooth-supporting tissue, leading to tooth loss. One of the main bacteria in the pathogenesis of periodontitis is Treponema denticola. Its involvement in periodontitis includes producing and releasing various virulence factors that further modulate inflammation and ignite alveolar bone destruction.To examine Treponema denticola's role in the mechanism of alveolar bone damage in periodontitis. Method: This systematic review was conducted from August 2021 until April 2022. Qualified literature is evaluated based on inclusion criteria, including published in English within the last ten years and research articles available in full text. The inclusion literature’s determination was based on the PRISMA (Preferred Reporting Item for Systematic Review and Meta-Analysis). Result: Six journals fit the inclusion criteria and discuss Treponema denticola involvement in alveolar bone destruction via several mechanisms, including periplasmic flagella as its virulence factor. Treponema denticola can inhibit osteogenic cell differentiation and induce the production TNF-α, IL-6, and IL1β, which are the proinflammatory cytokines involved in osteoclastogenesis. The induction mechanism of these various cytokines can ultimately increase osteoclast differentiation by increasing RANKL expression and decreasing OPG expression. Conclusion: Treponema denticola is involved in alveolar bone destruction by inhibiting bone formation and inducing an inflammatory response in immune cells that can increase osteoclast differentiation, as observed in alveolar bone destruction.

Item Type:	Article (Review)
Additional Information:	This is a collaborative paper with Faculty of Dentistry, Universitas Indonesia
Uncontrolled Keywords:	Treponema denticola; periodontitis; bone damage; bone cells
Subjects:	R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	Dr Widya Lestari
Date Deposited:	14 Mar 2024 12:02
Last Modified:	14 Mar 2024 14:05
URI:	http://irep.iium.edu.my/id/eprint/111372

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