Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)

Knights, Alexander J. and Vohralik, Emily J. and Houweling, Peter J. and Stout, Elizabeth S. and Norton, Laura J. and Alexopoulos, Stephanie J. and Yik, Jinfen. J. and Mat Jusoh, Hanapi and Olzomer, Ellen M. and Bell-Anderson, Kim S. and North, Kathryn N. and Hoehn, Kyle L. and Crossley, Merlin and Quinlan, Kate G. R. and UNSPECIFIED (2020) Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3). Nature Communications, 11. pp. 1-12. ISSN 2041-1723

	PDF (Article) - Published Version Restricted to Repository staff only Download (1MB) | Request a copy
Preview	PDF (SCOPUS) - Supplemental Material Download (250kB) | Preview

Abstract

The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellular and molecular changes reveal an accumulation of eosinophils in adipose tissue. We examine the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging. Furthermore, we provide evidence that eosinophils may directly act on adipocytes to drive beiging and highlight the critical role of these little-understood immune cells in thermogenesis

Item Type:	Article (Journal)
Subjects:	Q Science > QD Chemistry Q Science > QP Physiology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences
Depositing User:	Dr Hanapi Mat Jusoh
Date Deposited:	13 Feb 2024 11:27
Last Modified:	13 Feb 2024 16:04
URI:	http://irep.iium.edu.my/id/eprint/110784

Actions (login required)

View Item