Histological liver changes in streptozotocin induced diabetic mice

Al-Ani, Imad Matloub Dally and Al-Mishadani, Nu’man S and Muslih, Raad K. and Hamoodi , Salim R. (2009) Histological liver changes in streptozotocin induced diabetic mice. International Medical Journal Malaysia, 8 (1). ISSN 1823-4631

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Abstract

Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experiments were performed using a single dose of STZ (150mg/Kg. I.P.). Animals were killed two, four and six weeks after injection. The relative percentage of liver weight and liver histology were studied. The results showed several morphological and histological alterations in liver tissues, indicated by increase in the liver percentage of liver weight, glycogen reduction, associated with lipid deposition, inflammatory cells infiltration and Kupffer cells hyperplasia. Furthermore, this study illustrated the worsening of liver histology over a short time in STZ diabetic mice.

Item Type:	Article (Journal)
Additional Information:	5849/11004
Subjects:	Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited:	19 Dec 2011 15:41
Last Modified:	18 Dec 2015 10:48
URI:	http://irep.iium.edu.my/id/eprint/11004

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