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The impact of anticancer drugs on the ocular surface

Chiang, Jeremy Chung Bo and Zahari, Ilyanoon and Markoulli, Maria and Krishnan, Arun V. and Park, Susanna B. and Semmler, Annalese and Goldstein, David and Edwards, Katie (2020) The impact of anticancer drugs on the ocular surface. The Ocular Surface, 18 (3). pp. 403-413. ISSN 1542-0124

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Cancer is a global health problem and is one of the leading causes of death worldwide. Pleasingly, the rate of survival has improved and continues in an upward trend mainly due to better diagnosis and treatment modalities. In particular, the development of anticancer drugs including cytotoxic chemotherapy, hormonal agents and targeted therapies have provided the most effective treatment options in combatting cancerous cells. However, the antineoplastic mechanisms of these drugs can also lead to undesirable systemic and ocular side effects resulting from cytotoxicity, inflammation and neurotoxicity. While survival rates are projected to increase with time, the number of patients presenting with these side effects that can substantially impact quality of life will also rise. The current paper reviews the ocular surface and adnexal side effects of anticancer drugs, the appropriate management and possible interactions between drugs for ocular surface pathology treatment and the anticancer drugs.

Item Type: Article (Journal)
Uncontrolled Keywords: Anticancer drugs, chemotherapy, ocular surface, drug interactions, ocular adnexa, ocular side effects, hormonal agents, targeted therapies
Subjects: R Medicine > RE Ophthalmology > RE88 Ophthalmic nursing (Including eye, ear, nose and throat combined)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Allied Health Sciences
Kulliyyah of Allied Health Sciences > Department of Optometry and Visual Science
Depositing User: ilyanoon zahari
Date Deposited: 27 Dec 2023 11:03
Last Modified: 27 Dec 2023 11:15
URI: http://irep.iium.edu.my/id/eprint/109315

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