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The effect of lead exposure of mice during pregnancy on the concentration and motility of epididymal and testicular spermatozoa in offspring mature male mice

Al-Khfaji, Ina'am and Fakhrildin, Mohemed-Baqer and Al-Ani, Imad Matloub Dally and Mangalo, Hana'a and Al-Obaidi, Salim R. (2011) The effect of lead exposure of mice during pregnancy on the concentration and motility of epididymal and testicular spermatozoa in offspring mature male mice. International Medical Journal Malaysia, 10 (1). pp. 37-42. ISSN 1823-4631

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Abstract

Introduction: The objective of this study was to investigate the effects of lead on concentration and motility of spermatozoa recovered from epididymis and testes in mature male offspring whose mothers were exposed to different doses and concentrations of lead acetate during gestation period. Materials and Methods: Seventy two healthy mature female mice were divided into three major groups according to the number of injections involving 1, 2 and 3 injections. Each major group was subdivided into four minor groups according to the concentration dose of (0, 25, 50 and 100) mg/Kg of lead acetate. Sperm concentration, percentage of motility and grade of activity were microscopically examined and statistically analyzed. Results: A significant reduction in the sperm functions were seen in relation to an increased in the number of injections and/or concentration of lead acetate dose as compared with the control groups. Conclusion: The toxic effects of lead acetate may interfere with spermatogenesis and metabolism of spermatozoa.

Item Type: Article (Journal)
Additional Information: 5849/10713
Uncontrolled Keywords: Lead acetate, Spermatozoa, Sperm motility, Epididymis, Testis
Subjects: Q Science > QP Physiology
R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Assoc. Prof Dr.. Imad Matloub Dally Al-Ani
Date Deposited: 27 Jan 2012 08:10
Last Modified: 18 Dec 2015 02:46
URI: http://irep.iium.edu.my/id/eprint/10713

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