Effects of Eurycoma longifolia standardized extract on female reproductive disposition and perturbation pathways

Abdul Rahman, Suzanah (2018) Effects of Eurycoma longifolia standardized extract on female reproductive disposition and perturbation pathways. In: NKEA Agriculture EPP#1 High-value Herbal Products, Putrajaya. (Unpublished)

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Abstract

The present study shows that all doses of the Eurycoma longifolia standardised extracts (TAF 273) tested did not interfere with the normal oestrous cycle, hormones and morphology of the ovaries of the female rats upon treatment of 5 and 14 days. Eurycoma longifolia standardized extract may have potential in ameliorating the teratogenic effects of estradiol valerate by reducing external abnormalities in the rat foetuses and it also may have prospective use in the treatment of female-linked disorders and complications. TAF273 at a dose of 100 mg/kg has the potential to restore the oestrous cycle of the polycystic ovary rats as supported by the presence of numerous follicles in different stages of development and presence of corpora lutea suggesting the occurrence of ovulation in the immature female rats. Eurycoma longifolia standardized extract at dose of 100 mg/kg was found to have potential in ameliorating polycystic ovary syndrome induced by estradiol valerate by recovery of the oestrous cycle, improvement of the histopathology of PCOS-induced ovary and also attenuation of the reproductive hormones and steroidogenic genes.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	R Medicine > RA Public aspects of medicine > RA1190 Toxicology R Medicine > RG Gynecology and obstetrics R Medicine > RG Gynecology and obstetrics > RG133 Conception R Medicine > RG Gynecology and obstetrics > RG133.5 Reproductive technology > RG133.7 Ovulation induction R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Allied Health Sciences
Depositing User:	Prof. Dr. Suzanah Abdul Rahman
Date Deposited:	25 Sep 2023 15:04
Last Modified:	25 Sep 2023 15:11
URI:	http://irep.iium.edu.my/id/eprint/106902

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