Hydrophobic drug carrier from polycaprolactone-b-poly(ethylene glycol) star-shaped polymers hydrogel blend as potential for wound healing application

Ahmad Shariff, Siti Hajar and Daik, Rusli and Haris @ Harith, Muhammad Salahuddin and Ismail, Mohamad Wafiuddin (2023) Hydrophobic drug carrier from polycaprolactone-b-poly(ethylene glycol) star-shaped polymers hydrogel blend as potential for wound healing application. Polymers, 15 (9). pp. 1-22. E-ISSN 2073-4360

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Abstract

Blending hydrogel with an amphiphilic polymer can increase the hydrophobic drug loading and entrapment efficiency of hydrogel-based formulations. In this study, a hydrogel formulation with star-shaped polycaprolactone-b-poly(ethylene glycol) (PCL-b-PEG) as the hydrophobic drug cargo is produced. The 4-arm and 6-arm star-shaped PCL are synthesized with different molecular weights (5000, 10,000, 15,000 g/mol) via ROP and MPEG as the hydrophilic segment is attached via the Steglich esterification. FTIR and 1H-NMR analysis showed the presence of all functional groups for homopolymers and copolymers. Mn for all synthesized polymers is close to the theoretical value while GPC spectra showed a monomodal peak with narrow molecular weight distribution (PDI:1.01–1.25). The thermal degradation temperature and crystalline melting point of synthesized polymers increase with the increase in molecular weight and number of arms. All formulations possess high drug loading and entrapment efficiency (>99%) and increase with increasing molecular weight, number of arms, and amount of polymer in the formulations. All formulations showed a sustained drug release pattern with no initial burst, which follows the Korsmeyer–Peppas kinetic model. The polymer hydrogel formulations showed antibacterial activity against E. coli and S. aureus. The hydrogel containing 4-arm PCL15k-PEG is chosen as the best formulation due to its high drug release, good antimicrobial activity, and morphology.

Item Type:	Article (Journal)
Uncontrolled Keywords:	amphiphilic system; star-shaped polymer; hydrogel; polycaprolactone-b-poly(ethylene glycol)
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science Kulliyyah of Science > Department of Chemistry
Depositing User:	Dr Mohamad Wafiuddin Ismail
Date Deposited:	22 May 2023 09:11
Last Modified:	01 Jun 2023 11:07
URI:	http://irep.iium.edu.my/id/eprint/104654

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