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Delayed hypersensitivity reaction to allopurinol: a case report

Che' Man, Mohamad and Che Alhadi, Shahidah and Wan Mahmod, Wan Fatimah Suriyani and Amiruddin, Salman and Mohd Razib, Mohd Zhafri and Ismail, Rasimah (2023) Delayed hypersensitivity reaction to allopurinol: a case report. Malaysian Family Physician, 18 (11). pp. 1-3. ISSN 1985-207X E-ISSN 1985-2274

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Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management.

Item Type: Article (Case Report)
Uncontrolled Keywords: Delayed hypersensitivity, Allopurinol, Rashes, Xanthine Oxidase Inhibitor
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine
R Medicine > RD Surgery
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Kulliyyah of Medicine > Department of Internal Medicine
Kulliyyah of Medicine > Department of Surgery
Date Deposited: 24 Feb 2023 08:45
Last Modified: 24 Feb 2023 08:47
URI: http://irep.iium.edu.my/id/eprint/103775

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