Tualang honey supplementation alleviates obesity and dyslipidaemia in high cholesterol diet induced non-alcoholic steatohepatitis animal model

Alias, Mohd Afzal and Abdul Rahim, Roslina and Muhammad, Naznin and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Ahmad Affandi, Khairunisa (2022) Tualang honey supplementation alleviates obesity and dyslipidaemia in high cholesterol diet induced non-alcoholic steatohepatitis animal model. IIUM Medical Journal Malaysia, 21 (4). pp. 105-113. ISSN 1823-4631 E-ISSN 2735-2285

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Abstract

INTRODUCTION: Dyslipidaemia and obesity are two main features of non-alcoholic steatohepatitis (NASH). This study aimed to investigate the effects of Tualang honey (TH) supplementation on bodyweight, liver weight, and lipid profiles in high cholesterol diet (HCD) induced NASH animal model. MATERIALS AND METHODS: Sixteen Sprague-Dawley rats were given 12% HCD for 16 weeks to induce NASH. These animals were divided into 4 groups; Group 1 (continued HCD), Group 2 (changed to normal diet), Group 3 (normal diet and TH 1.2g/kg) and Group 4 (normal diet and TH 3.0g/kg) for the following 4 weeks. Bodyweight was measured daily. At the end of the study, blood was collected via retro-orbital bleeding and the rats were sacrificed to harvest their liver. RESULTS: The group 4 rats had significantly lower mean final bodyweight than rats in group 1, 2 and 3 (478.0±24.4 vs. 641.5±25.1, 593.8 ±29.3, 552.0±72.9 g, p<0.05). Animals in group 4 were also found to have a significantly lower mean liver weight compared to groups 1 and 2 (12.9±0.9 vs 20.1±2.2, 15.7±1.2 g, p<0.05). In comparison to controls, the mean concentration of total cholesterol was significantly lower in all the other groups and the lowest mean concentration of triglycerides was recorded in group 4 with significant difference when compared to the controls (0.9±0.4 vs 3.6±0.4 mmol/L, p<0.05). CONCLUSION: The change from HCD to a normal diet coupled with TH supplementation has been shown to reduce bodyweight, liver weight, total cholesterol and triglyceride levels in the 12% HCD NASH induced animal models

Item Type:	Article (Journal)
Uncontrolled Keywords:	Non-alcoholic steatohepatitis, obesity, tualang honey, dyslipidaemia, animal mode
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC620 Specialties of Internal Medicine-Nutritional Diseases R Medicine > RC Internal medicine > RC627 Specialties of Internal Medicine-Metabolic Diseases R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM214 Diet therapy. Diet and dietectics in disease R Medicine > RM Therapeutics. Pharmacology > RM216 Diet Therapy. Clinical Nutrition R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Dr ROSLINA ABDUL RAHIM
Date Deposited:	04 Oct 2022 08:59
Last Modified:	04 Oct 2022 08:59
URI:	http://irep.iium.edu.my/id/eprint/100424

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