Muhaimin, Muhaimin and Lestari, Uce and Hirzan, Rifanza and Chaerunisaa, Anis Yohana and Khatib, Alfi (2026) Antihypertensive plants used by the Anak Dalam tribe in Jambi, Indonesia: ethnobotanical insights and pharmacological potential as alternatives to conventional medicine. Drug Design, Development and Therapy, 20 (NA). pp. 1-37. E-ISSN 2774-0226
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Abstract
Hypertension represents a significant health burden worldwide, and traditional medicinal plants historically used by indigenous communities such as the Anak Dalam tribe to manage blood pressure offer promising ethnopharmacological opportunities for developing accessible and culturally acceptable antihypertensive therapies. This review summarizes the traditional uses of 34 wellknown and promising medicinal plants utilized by the Anak Dalam tribe and assesses their potential for treating hypertension-related diseases. The results revealed that nine medicinal plants used by the Anak Dalam tribe in Jambi, Indonesia, in developing antihypertensive therapies. In this study, the medicinal properties of the following species are discussed briefly, and their benefits are highlighted: turmeric (Curcuma longa Linn). garlic (Allium sativum Linn). noni (Morinda citrifolia Linn). lime (Citrus aurantiifolia (Christm). Swingle), celery (Apium graveolens Linn). starfruit (Averrhoa bilimbi Linn). cat’s whiskers (Orthosiphon aristatus var. aristatus), soursop (Annona muricata L). and ginger (Zingiber officinale Roscoe). According to the review of the literature, these plants were tested using various methods: turmeric and partially celery on male Wistar rats induced with deoxycorticosterone acetate (DOCA); garlic in a randomized clinical trial; noni with 8% NaCl and prednisone induction; lime in a heated palm oil model; bilimbi with 0.8% NaCl induction and human patients; cat’s whiskers in phenylephrine-induced rats and a clinical cohort; soursop on normotensive and ethanol/sucrose/epinephrine-induced rats; and ginger by an unspecified invasive method. Data from the references suggest that the extracts reliably show notable decreases in blood pressure and adjustments in heart rate, mainly due to their elevated levels of flavonoids, phenolics, organosulfurs, coumarins, phthalides, and acetogenins compounds known for their antihypertensive effects. Although encouraging, additional studies are needed to create safe and effective pharmaceutical products derived from these plants. They have the potential to serve as a natural alternative to synthetic antihypertensive medications, possibly providing comparable results with fewer adverse effects. Furthermore, this review serves as an important reference for future studies on ethnomedicines that contain phytochemicals.
| Item Type: | Article (Review) |
|---|---|
| Additional Information: | Alfi Khatib is the first IIUM author |
| Uncontrolled Keywords: | antihypertension, herbal medicine, traditional medicine, phytochemicals, anak dalam tribe |
| Subjects: | R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry |
| Depositing User: | Dr. Alfi Khatib |
| Date Deposited: | 21 Sep 2026 16:17 |
| Last Update: | 21 Sep 2026 16:17 |
| Queue Number: | 2026-09-Q5167 |
| URI: | http://irep.iium.edu.my/id/eprint/131353 |
| Indexed In: | WOS and SCOPUS, ERA, Google Scholar |
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