Abd. Rahim, Nour El Huda and Zulkifly, Ahmad Hafiz and Mohd Jan, Nurul Hafiza and Mohamad Amri, Nur Fathonah and Ibrahim, Mohd Zulfadzli and Mohamed, Farahidah and Abu Hassan, Salmah Anim and Nasuruddin, Muhammad Haidar (2026) In Vivo study of intra-articular Tualang honey formulation as a potential alternative to Synvisc® in an osteoarthritic rabbit model. Malaysian Orthopaedic Journal, 20 (1). pp. 139-148. ISSN 1985-2533 E-ISSN 2232-111X
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Abstract
Introduction: Osteoarthritis (OA) is a degenerative joint disorder characterised by cartilage degradation and inflammation. This study evaluates the efficacy of Tualang Honey Formulation (THF) (Patent no. MY-179303-A), a natural-based formulation tested for biocompatibility and toxicity, compared to Synvisc, a conventional hyaluronic acid injection, in managing OA in vivo using an animal model. Materials and methods: Twenty-eight New Zealand White Rabbits (NZWR) were operated to surgically induce OA and divided into three groups: sham group (n=1), THF-treated group (n=3) and Synvisc-treated group (n=3). Treatments were administered intra-articularly three weeks post-surgery. Radiographic assessments were performed at 3, 6, 12, and 24 weeks. Histological analyses at 24 weeks utilised Masson�Goldner trichrome staining. Results: In the sham group, severe cartilage loss, thinning, and thickened subchondral bone were observed, reflecting progressive OA. Radiographically, both THF and Synvisc groups demonstrated improved joint space and reduced subchondral sclerosis. At six weeks, the THF and Synvisc groups exhibited improvements from three weeks. At 12 weeks, the THF group demonstrated better joint space preservation, while outcomes were comparable at 24 weeks. Histologically, the THF group displayed thicker articular surfaces with signs of bone remodelling with better cartilage preservation. In contrast, Synvisc-treated joints displayed thinner, irregular cartilage and subchondral bone changes, suggestive of potential bone cyst formation. Conclusion: THF is equally effective as Synvisc in reducing OA progression while showing additional benefits in cartilage preservation and bone remodelling. As a natural and local product, THF represents a promising alternative viscosupplement for OA management, warranting further clinical validation.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | Tualang honey, synvisc, osteoarthritis, rabbit model, viscosupplement |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RD Surgery R Medicine > RD Surgery > RD701 Orthopedics |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation |
| Depositing User: | Dr Nour El Huda Abd Rahim |
| Date Deposited: | 13 Apr 2026 10:00 |
| Last Modified: | 13 Apr 2026 10:00 |
| Queue Number: | 2026-04-Q2764 |
| URI: | http://irep.iium.edu.my/id/eprint/128214 |
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