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The mechanisms of probiotics, prebiotics, synbiotics, and postbiotics in oral cancer management

Mohd Fuad, Aalina Sakiinah and Amran, Nurul Aqilah and Nasruddin, Nurrul Shaqinah and Burhanudin, Nor Aszlitah and Dashper, Stuart and Arzmi, Mohd Hafiz (2022) The mechanisms of probiotics, prebiotics, synbiotics, and postbiotics in oral cancer management. Probiotics and Antimicrobial Proteins. pp. 1-14.

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Oral carcinogenesis is preceded by oral diseases associated with inflammation such as periodontitis and oral candidiasis, which are contributed by chronic alcoholism, smoking, poor oral hygiene, and microbial infections. Dysbiosis is an imbal- ance of microbial composition due to oral infection, which has been reported to contribute to oral carcinogenesis. Therefore, in this review, we summarised the role of probiotics, prebiotics, synbiotics, and postbiotics in promoting a balanced oral microbiome, which may prevent oral carcinogenesis due to oral infections. Probiotics have been shown to produce biofilm, which possesses antibacterial activity against oral pathogens. Meanwhile, prebiotics can support growth and increase the benefit of probiotics. In addition, postbiotics possess antibacterial, anticariogenic, and anticancer properties that potentially aid in oral cancer prevention and treatment. The use of probiotics, prebiotics, synbiotics, and postbiotics for oral cancer management is still limited despite their vast potential, thus, discovering their prospects could herald a novel approach to disease prevention and treatment while participating in combating antimicrobial resistance.

Item Type: Article (Journal)
Uncontrolled Keywords: Probiotic; Prebiotic; Synbiotic; Postbiotic; Oral cancer management
Subjects: Q Science > QR Microbiology
R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Dentistry
Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User: Dr Mohd Hafiz Arzmi
Date Deposited: 12 Sep 2022 10:35
Last Modified: 12 Sep 2022 11:01
URI: http://irep.iium.edu.my/id/eprint/99946

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