A review with updated perspectives on the antiviral potentials of traditional medicinal plants and their prospects in antiviral therapy

Saifulazmi, Nur Fadlin and Rohani, Emelda Rosseleena and Harun, Sarahani and Bunawan, Hamidun and Hamezah, Hamizah Shahirah and Nor Muhammad, Nor Azlan and Azizan, Kamalrul Azlan and Ahmed, Qamar Uddin and Fakurazi, Sharida and Mediani, Ahmed and Sarian, Murni Nazira (2022) A review with updated perspectives on the antiviral potentials of traditional medicinal plants and their prospects in antiviral therapy. Life, 12 (8). pp. 1287-1324. ISSN 2075-1729

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Abstract

: Exploration of the traditional medicinal plants is essential for drug discovery and development for various pharmacological targets. Various phytochemicals derived from medicinal plants were extensively studied for antiviral activity. This review aims to highlight the role of medicinal plants against viral infections that remains to be the leading cause of human death globally. Antiviral properties of phytoconstituents isolated from 45 plants were discussed for five different types of viral infections. The ability of the plants’ active compounds with antiviral effects was highlighted as well as their mechanism of action, pharmacological studies, and toxicological data on a variety of cell lines. The experimental values, such as IC50, EC50, CC50, ED50, TD50, MIC100, and SI of the active compounds, were compiled and discussed to determine their potential. Among the plants mentioned, 11 plants showed the most promising medicinal plants against viral infections. Sambucus nigra and Clinacanthus nutans manifested antiviral activity against three different types of viral infections. Echinacea purpurea, Echinacea augustofolia, Echinacea pallida, Plantago major, Glycyrrhiza uralensis, Phyllanthus emblica, Camellia sinensis, and Cistus incanus exhibited antiviral activity against two different types of viral infections. Interestingly, Nicotiana benthamiana showed antiviral effects against mosquito-borne infections. The importance of phenolic acids, alkamides, alkylamides, glycyrrhizin, epicatechin gallate (ECG), epigallocatechin gallate (EGCG), epigallocatechin (EGC), protein-based plant-produced ZIKV Envelope (PzE), and anti-CHIKV monoclonal antibody was also reviewed. An exploratory approach to the published literature was conducted using a variety of books and online databases, including Scopus, Google Scholar, ScienceDirect, Web of Science, and PubMed Central, with the goal of obtaining, compiling, and reconstructing information on a variety of fundamental aspects, especially regarding medicinal plants.

Item Type:	Article (Journal)
Additional Information:	4921/99712
Uncontrolled Keywords:	medicinal plants; virus infections; antiviral activities; bioactive compounds
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	30 Aug 2022 10:22
Last Modified:	30 Aug 2022 10:35
URI:	http://irep.iium.edu.my/id/eprint/99712

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