Histological and immunohistochemical study of the protective effect of virgin coconut oil on cyclophosphamide-induced immunotoxicity of the spleen and peyer’s patches

AlJoufi, Fakhria A. AlJoufi and M. Senin, Mu’izuddin and I.Matloub, Gheed and A. Wahab Alsiadi, Wasan and Al-Ani, Imad M. and Mustafa Mahmoud, Mohammed Imad Al-Deen and S.Ahmed, Fakhri and Najm Abed, Shaymaa (2022) Histological and immunohistochemical study of the protective effect of virgin coconut oil on cyclophosphamide-induced immunotoxicity of the spleen and peyer’s patches. International Journal of Health Sciences, 6 (2). pp. 1092-1107. ISSN 2550-6978 E-ISSN 2550-696X

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Abstract

Introduction: Virgin coconut oil (VCO) is an edible oil extracted from the meat of mature coconuts. It is also known for its health and therapeutic benefits, mainly attributed to its polyphenols and medium-chain fatty acid contents The immunomodulatory effects of VCO have not been extensively investigated. The aim of the present study was to investigate the effects of VCO on cyclophosphamide (CY)-induced immunotoxicity of peripheral lymphoid tissues. Methods: Forty Wistar rats were divided into five groups of eight rats each. Group 1 served as the normal control, while the other groups were all given 10 mg/kg of CY orally once daily for 4 weeks. Group 2 received CY served as the negative control. Group 3 rats were treated with levamisole (LMS) for 6 weeks, while Groups 4A and 4B were given VCO at 10 mL/kg and 15 mL/kg, respectively, for 6 weeks. The spleen and ileum sections were subjected to routine histological examination and immunohistochemical evaluation for T and B lymphocytes. Results: Histologically, the spleen and Peyer’s patches (PPs) of the ileum exhibited a significant reduction in the lymphoid cellularity following daily administration of 10 mg/kg CY for 4 weeks.

Item Type:	Article (Journal)
Uncontrolled Keywords:	cyclophosphamide, immunotoxicity, levamisole, Peyer’s patches, spleen, virgin coconut oil.
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Sakinah Kamaludin
Date Deposited:	12 Sep 2022 08:51
Last Modified:	12 Sep 2022 08:51
URI:	http://irep.iium.edu.my/id/eprint/99625

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