Effect of B12 supplementation on renal anemia among hemodialysis patients at El-Najar hospital, Gaza strip

Nahas, Abdul Rahman Fata and Al Zarzour, Raghdaa Hamdan and Abu Laila, Asmaa Salama M. and Tabash, Ahmed Mahmoud and Abu Mustafa, Ayman Mustafa and Mohamad Allyan, Faten and Elregeb, Abdrabbou Mohammed and Abou Teior, Eyad Elabed and Al-Shami, Abdulkareem Mohammed and Elnaem, Mohamed Hassan Abdelaziz (2022) Effect of B12 supplementation on renal anemia among hemodialysis patients at El-Najar hospital, Gaza strip. Journal of Renal Injury Prevention, 11. pp. 1-5. E-ISSN 2345-2781

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Abstract

Introduction: Patients with end-stage renal disease (ESRD) are predisposed to nutritional deficiencies, resulting in vitamin B12 deficiency with negative hematologic consequences. Objective: This study aimed to investigate the impact of intramuscular B12 on renal anemia among ESRD patients receiving hemodialysis (HD) at El-Najar hospital, Gaza Strip. Patients and Methods: A case-control study conducted, which included 110 healthy controls and 110 HD patients who received B12 on a daily, weekly, and monthly basis over two months. Sociodemographics and current diseases were reported. Serum levels of serum B12, white blood cell (WBC), red blood cell (RBC), hemoglobin (Hb), mean corpuscular volume (MCV), and platelet (PLT) were recorded before and after treatment. Data analysis was conducted using SPSS. Results: Baseline serum B12 level was significantly lower in HD patients compared to controls (362.62 ± 166.40 versus 483.36 ± 115.07 ρg/mL, P<0.001), which significantly improved after vitamin B12 treatment (639.08 ± 362.99 ρg/mL, P<0.001). Additionally, mean WBCs, RBCs, Hb, and PLT levels were significantly increased after treatment (P<0.001). Serum B12 level was positively and significantly (P<0.001) correlated with levels of WBC (r = 0.45), RBC (r = 0.43), Hb (r = 0.39) and PLT (r = 0.51), and negatively correlated with MCV (r = -0.46, P<0.001). Conclusion: Administration of vitamin B12 improves serum B12 levels in HD patients, which was associated with increased WBCs, RBCs, Hb, and PLT levels and decreased MCV levels. Treatment by vitamin B12 can improve HD patients’ renal anemia. Future studies with larger sample sizes and prolonged follow-up are advocated.

Item Type:	Article (Journal)
Uncontrolled Keywords:	End stage renal disease, Gaza strip, Hemodialysis, Hematological indices, Vitamin B12
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Dr Mohamed Elnaem
Date Deposited:	18 Jul 2022 09:08
Last Modified:	22 Jul 2022 11:37
URI:	http://irep.iium.edu.my/id/eprint/98824

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