Abdull Jalil, Mohd Asyraf and Abd Rahim, Nour El Huda and Mohd Noor, Hanisah and Harun, Noorul Amilin and A. Talib, Norlelawati (2022) Association between DNA methylation of the CUB and sushi multiple domains 1 gene and schizophrenia. Asia Pacific Journal of Molecular Biology and Biotechnology, 30 (2 (Supplementary)). p. 35. ISSN 0128-7451 E-ISSN 2672-7277
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Abstract
Introduction: The CUB and Sushi multiple domains 1 protein (CSMD1) inhibits the complement cascade in neural tissues. Complement activation in the brain has been proposed as one of the pathogeneses for schizophrenia by causing excessive synapse pruning. A variant of the CSMD1 gene is also associated with schizophrenia at genome-wide level and is linked with cognitive impairment. However, there is lack of study on DNA methylation of CSMD1 in schizophrenia. Therefore, this study investigated the levels of CSMD1 DNA methylation in schizophrenia and the relationship with symptom severity. Methods: In this case-control study, DNA methylation levels of CSMD1 were compared between 183 schizophrenia patients (SZ) and 212 healthy controls (HC). The DNA methylation levels were quantified using MethyLight quantitative PCR assay on bisulfite-modified genomic DNA, purified from peripheral blood. The methylation levels were measured as percentage of methylated reference (PMR). Symptom severity was assessed in SZ using the Positive and Negative Syndrome Scale (PANSS). Results: There were lower CSMD1 PMR values in SZ compared to HC (p = 0.001). Additionally, there were negative correlation between CSMD1 PMR values and positive PANSS scores (rs = -0.206, p = 0.005). Age and ethnicity were also associated with CSMD1 PMR values. Conclusion: These results suggest that hypomethylation of CSMD1 could be one of the molecular bases for schizophrenia. Nevertheless, these results must be verified, and the mechanism of association must be determined in future studies.
| Item Type: | Article (other) |
|---|---|
| Uncontrolled Keywords: | DNA methylation, CSMD1, Schizophrenia |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine |
| Depositing User: | Dr Mohd Asyraf Abdull Jalil |
| Date Deposited: | 15 Jul 2022 09:57 |
| Last Modified: | 21 Jul 2022 12:39 |
| URI: | http://irep.iium.edu.my/id/eprint/98774 |
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