Acetaminophen synthesis and encapsulation using safe mixed-solvents and solution enhanced dispersion by supercritical CO2

Islam, Tariqul and Sarker, Md. Zaidul Islam Sarker and Helal Uddin, A.B.M. and Lee, Richard Smith Jr (2022) Acetaminophen synthesis and encapsulation using safe mixed-solvents and solution enhanced dispersion by supercritical CO2. The Journal of supercritical fluid, 188. pp. 1-9. ISSN 0896-8446

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Abstract

Acetaminophen (ACMP) was synthesized in mixed-solvents (H2O-acetone, H2O-dimethyl sulfoxide, H2O-isopropyl alcohol) for purposes of eliminating hazardous dipolar aprotic solvents. The H2O-acetone solvent-pair gave synthesized ACMP yields of 79.2%. Synthesized ACMP samples were encapsulated using solution enhanced dispersion by supercritical CO2 (SEDS) at 150 bar, 45 ◦C, 1.5 mL/min feed flow rate (30 mg ACMP/mL in mixed-solvent), CO2 flow rate of 15 L/min (1 bar, 25 ◦C) in which suitable products could not be formed with PEG-4000 excipient at ACMP:PEG ratios of 1:1 with mixed-solvents, however, with ethyl cellulose (EC) excipient at ACMP:EC ratios of 1:1 and ethanol-acetone mixed-solvent (x:y, v/v, x = 1–9, y = 9–1), encapsulated products could be formed over the full range of mixed-solvent compositions. ACMP encapsulated fine particles had purities as high as 99.9% demonstrating that SEDS with safe mixed-solvents can broaden methods available for encapsulating pharmaceuticals.

Item Type:	Article (Journal)
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology > RM300 Drugs and their action R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. A. B. M. Helal Uddin
Date Deposited:	07 Jul 2022 10:30
Last Modified:	07 Jul 2022 10:30
URI:	http://irep.iium.edu.my/id/eprint/98711

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