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Sepsis and Its impact on outcomes in elderly patients admitted to a Malaysian intensive care unit

Wan Shukeri, Wan Fadzlina and Mat Nor, Mohd Basri and Md Ralib, Azrina (2022) Sepsis and Its impact on outcomes in elderly patients admitted to a Malaysian intensive care unit. The Malaysian Journal of Medical Sciences (MJMS), 29 (3). pp. 145-150. ISSN 1394-195X E-ISSN 2180-4303

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Sepsis is an important cause of morbidity and mortality in elderly patients, but there is a scarcity of data on sepsis in this specific cohort. We performed this study to review the impact of sepsis on outcomes in elderly patients admitted to our local intensive care unit (ICU). This was a secondary analysis of prospectively collected data of 159 consecutive adult patients with sepsis admitted to an ICU of a tertiary hospital in Malaysia over a three-year period. Of the 159 patients analysed, elderly patients constituted 18.9% of the cohort. Fifty percent of the older patients died within 30 days, compared to 24% of younger patients (P = 0.005). On multivariate analysis, old age was found to be independently predictive of 30-day mortality with an adjusted odds ratio (OR) of 2.5 (95% confidence interval [CI]: 1.05, 6.01) compared to younger patients (P = 0.021). In a Kaplan-Meier analysis, survival probability was significantly lower in patients of an older age compared to younger patients (P = 0.015). In conclusion, mortality from sepsis is considerably higher in elderly patients, with age as an independent risk factor for mortality.

Item Type: Article (Journal)
Uncontrolled Keywords: elderly, sepsis, septic shock, mortality, intensive care unit
Subjects: R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care
Kulliyyah of Medicine
Depositing User: Dr. Mohd Basri Mat Nor
Date Deposited: 04 Jul 2022 16:15
Last Modified: 04 Jul 2022 16:17
URI: http://irep.iium.edu.my/id/eprint/98657

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