Biocampatible supramolecular mesoporous silica nanoparticles as the next-generation drug delivery system

Mohamed, Farahidah and Oo, May K. and Chatterjee, Bappaditya and Alallam, Batoul (2022) Biocampatible supramolecular mesoporous silica nanoparticles as the next-generation drug delivery system. Frontiers in Pharmacology, 13. pp. 1-7. ISSN 1663-9812

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Abstract

Supramolecular mesoporous silica nanoparticles (MSNs) offer distinct properties as opposed to micron-sized silica particles in terms of their crystal structure, morphology–porosity, toxicity, biological effects, and others. MSN biocompatibility has touched the pharmaceutical realm to exploit its robust synthesis pathway for delivery of various therapeutic molecules including macromolecules and small-molecule drugs. This article provides a brief review of MSN history followed by special emphasis on the influencing factors affecting morphology–porosity characteristics. Its applications as the next-generation drug delivery system (NGDDS) particularly in a controlled release dosage form via an oral drug delivery system are also presented and shall be highlighted as oral delivery is the most convenient route of drug administration with the economical cost of development through to scale-up for clinical trials and market launch.

Item Type:	Article (Journal)
Uncontrolled Keywords:	mesoporous, silica, nanoparticles, insulin, pharmaceutical, oral
Subjects:	R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Assoc Prof Farahidah Mohamed
Date Deposited:	30 Jun 2022 16:13
Last Modified:	29 Sep 2022 15:40
URI:	http://irep.iium.edu.my/id/eprint/98592

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