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Biotransformation of curcumin and structure–activity relationship (SAR) of its analogues: a systematic review

Aminudin, Nurul Iman and Amran, Nurul Aqilah and Zainal Abidin, Zaima Azira and Darnis, Deny Susanti (2022) Biotransformation of curcumin and structure–activity relationship (SAR) of its analogues: a systematic review. Biocatalysis and Biotransformation. ISSN 1024-2422 E-ISSN 1029-2446

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Abstract

Curcumin has been widely acclaimed for several pharmacological properties, such as antioxidant, antimicrobial, anticancer, and anti-inflammation. Curcumin’s poor aqueous solubility, bioavailability, and cellular uptake hamper its ability to display maximum pharmacological effect in the human body. Synthesis of curcumin analogues to enhance its properties can be achieved through biotransformation. Greener, simpler, and higher selectivity and specificity make biotransformation an alternative approach when preparing curcumin analogues for the structure– activity relationship (SAR) study intended for drug design. This work systematically reviews the biotransformation of curcumin by utilizing fungi, gut microbiota, and enzymes. The SAR study of curcumin and its analogues for several bioactivities is also highlighted.

Item Type: Article (Journal)
Uncontrolled Keywords: curcumin; biocatalysts; structure–activity relationship; systematic review; gut microbiota
Subjects: Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Science > Department of Chemistry
Kulliyyah of Science
Depositing User: Dr Nurul Iman Aminudin
Date Deposited: 24 Jun 2022 17:28
Last Modified: 24 Jun 2022 17:28
URI: http://irep.iium.edu.my/id/eprint/98457

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