Efficacy of nondiuretic pharmacotherapy for improving the treatment of congestion in patients with acute heart failure: a systematic review of randomised controlled trials

Emara, Abdulrahman N. and Mansour, Noha O. and Elnaem, Mohamed Hassan Abdelaziz and Wadie, Moheb and Dehele, Inderpal Singh and Shams, Mohamed (2022) Efficacy of nondiuretic pharmacotherapy for improving the treatment of congestion in patients with acute heart failure: a systematic review of randomised controlled trials. Journal of Clinical Medicine, 11 (11). E-ISSN 2077-0383

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Abstract

Diuretic therapy is the mainstay during episodes of acute heart failure (AHF). Diuretic resistance is often encountered and poses a substantial challenge for clinicians. There is a lack of evidence on the optimal strategies to tackle this problem. This review aimed to compare the outcomes associated with congestion management based on a strategy of pharmacological nondiuretic-based regimens. The PubMed, Cochrane Library, Scopus, and ScienceDirect databases were systematically searched for all randomised controlled trials (RCTs) of adjuvant pharmacological treatments used during hospitalisation episodes of AHF patients. Congestion relief constitutes the main target in AHF; hence, only studies with efficacy indicators related to decongestion enhancement were included. The Cochrane risk-of-bias tool was used to evaluate the methodological quality of the included RCTs. Twenty-three studies were included; dyspnea relief constituted the critical efficacy endpoint in most included studies. However, substantial variations in dyspnea measurement were found. Tolvaptan and serelaxin were found to be promising options that might improve decongestion in AHF patients. However, further high-quality RCTs using a standardised approach to diuretic management, including dosing and monitoring strategies, are crucial to provide new insights and recommendations for managing heart failure in acute settings.

Item Type:	Article (Review)
Uncontrolled Keywords:	acute heart failure; decongestion; decompensation; dyspnea; adjuvant; tolvaptan; serelaxin; acute decompensated heart failure; levosimendan; empagliflozin
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Dr Mohamed Elnaem
Date Deposited:	02 Jun 2022 11:23
Last Modified:	15 Jul 2022 08:31
URI:	http://irep.iium.edu.my/id/eprint/98149

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