Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation

Shamsudin, Nur Farisya and Ahmed, Qamar Uddin and Mahmood, Syed and Shah, Syed Adnan Ali and Khatib, Alfi and Mukhtar, Sayeed and Alsharif, Meshari A. and Parveen, Humaira and Zakaria, Zainul Amiruddin (2022) Antibacterial effects of flavonoids and their structure-activity relationship study: a comparative interpretation. Molecules, 27 (4). pp. 1-43. ISSN 1420-3049

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Abstract

According to the latest report released by the World Health Organization, bacterial resistance to well-known and widely available antibacterial drugs has become a significant and severe global health concern and a grim challenge to tackle in order to cure infections associated with multidrug-resistant pathogenic microorganisms efficiently. Consequently, various strategies have been orchestrated to cure the severe complications related to multidrug-resistant bacteria effectively. Some approaches involved the retardation of biofilm formation and multidrug-resistance pumps in bacteria as well as the discovery of new antimicrobial agents demonstrating different mechanisms of action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, flavonoids, saponins, tannins, etc., have been suggested to tackle the multidrug-resistant bacterial strains owing to their versatile pharmacological effects. Amongst these, flavonoids, also known as polyphenolic compounds, have been widely evaluated for their antibacterial property due to their tendency to retard the growth of a wide range of pathogenic microorganisms, including multidrugresistant bacteria. The hydroxylation of C5, C7, C30, and C40; and geranylation or prenylation at C6 have been extensively studied to increase bacterial inhibition of flavonoids. On the other hand, methoxylation at C30 and C5 has been reported to decrease flavonoids’ antibacterial action. Hence, the latest information on the antibacterial activity of flavonoids is summarized in this review, with particular attention to the structure–activity relationship of this broad class of natural compounds to discover safe and potent antibacterial agents as natural products.

Item Type:	Article (Journal)
Uncontrolled Keywords:	antibacterial effects; structure activity relationship studies; natural products; pharmacophores
Subjects:	Q Science > QD Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry Kulliyyah of Pharmacy
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	13 May 2022 12:03
Last Modified:	13 May 2022 12:03
URI:	http://irep.iium.edu.my/id/eprint/97913

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