Tualang honey’s spermatoprotective effects in a model of high cholesterol diet-induced animals

Hasan, Sakinah and Abdul Rahim, Roslina and Alias, Mohd Afzal and Muhammad, Siti Aeshah @ Naznin and Abdullah, Nor Zamzila and Abdul Razak, Redzuan Nul Hakim (2022) Tualang honey’s spermatoprotective effects in a model of high cholesterol diet-induced animals. PHARMACOPHORE, 13 (1). ISSN 2229-5402

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Abstract

This investigation intended to ascertain the Tualang Honey’s (TH) spermatoprotective effects on the reproductive system of male rats on a high-cholesterol diet (HCD). The animal study was conducted at the Department of Basic Medical Science, Kulliyyah of Medicine, IIUM. Twenty-four Sprague Dawley rats were fed with a 12% HCD for 16 weeks. Then, they were divided into four subgroups (group H1, H2, H3, and H4) and continued on the 12% HCD. This was conducted in addition to the administration of distilled water, 1.2, 2.4, and 3.0 g of honey per kg body weight daily, respectively for four weeks. By end of the fourth week, all rats were killed, and blood samples were brought for biochemical analysis as the testis and epididymis were gathered for histology and sperm analysis. All TH supplemented groups showed enormous improvements in the sperm parameters (sperm concentration, motility, progressive motility, normal morphology, and viability) in comparison to H1 (P < .001). The higher the TH dosage, the greater the improvements in the normal sperm morphology. In conclusion, the TH supplementation improved the sperm analysis results in the animal model, hence exerting the spermatoprotective effects.

Item Type:	Article (Journal)
Uncontrolled Keywords:	High cholesterol diet, Tualang honey, Male reproductive system, Animal study
Subjects:	Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology R Medicine > RM Therapeutics. Pharmacology > RM214 Diet therapy. Diet and dietectics in disease
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr ROSLINA ABDUL RAHIM
Date Deposited:	04 Mar 2022 08:38
Last Modified:	07 Apr 2022 09:25
URI:	http://irep.iium.edu.my/id/eprint/97047

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