A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models

Ismail, Anis Farihan and Mohd Nasir, Suriati and Tuan Ismail, Tuan Salwani and Wan Ahmad, Wan Amir Nizam and Wan Abdul Rahman, Wan Faiziah and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Tengku Din, Tengku Ahmad Damitri Al-Astani (2021) A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models. Malaysian Applied Biology, 50 (2). pp. 151-156. ISSN 2462-151X

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Abstract

Diabetes is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. SBH has good antihyperglycemic potential and has traditionally been used as an alternative treatment for diabetes mellitus (DM). Since the role of SBH in glucose control is still unclear in animal and human studies, the present study was designed to evaluate the antihyperglycemic effects of SBH in streptozotocin-induced diabetic rat models. Fifteen Sprague-Dawley rats (200-250 g) were equally divided into five groups, the first group being a normal (non-diabetic) rat and the other four groups being diabetic. The normal and untreated diabetic groups received normal saline while the other diabetic groups were treated with SBH (2 g/kg body weight), metformin (MET /250 mg/kg body weight) and SBH + MET respectively.The treatment was given within 12 days. Fasting blood glucose (FBG) was measured at baseline and every two weeks thereafter. On days 7 and 12, SBH significantly lowered FBG, comparable to the normal group (p<0.05). In the group treated with MET and the combination of SBH-MET, FBG improved only on the 12th day of treatment (p<0.05). The results show that a single SBH treatment is effective in lowering blood glucose levels. Thus, SBH could be of great value in the treatment of diabetes in humans

Item Type:	Article (Journal)
Uncontrolled Keywords:	Antihyperglycemic, diabetes mellitus, fasting blood glucose, Stingless bee honey, STZ-induced diabetic rats
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Mrs Norsyafini Ahmad Marzuki
Date Deposited:	30 Dec 2021 11:58
Last Modified:	30 Dec 2021 11:58
URI:	http://irep.iium.edu.my/id/eprint/95752

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